Gunnar Henderson homered in the first inning and the Baltimore Orioles later tore through Chicago’s bullpen, winning 13-3 to hand the visiting White Sox their 11th straight loss Monday.

Cedric Mullins had three hits, including a homer, and drove in three runs, Austin Slater added three hits and three RBIs and Henderson also knocked in three runs. Emmanuel Rivera, Ryan O’Hearn, Adley Rutschman, Colton Cowser and Jackson Holliday each had two hits for Baltimore, which has won three of its past four games.

Orioles starter Corbin Burnes settled in after giving up two first-inning runs. He completed five innings, allowing six hits and striking out four, to secure his first victory in his past five starts.

Keegan Akin and Cole Irvin, who notched a three-inning save, worked in relief for the Orioles.

White Sox starter Chris Flexen (2-14) gave up three runs on seven hits in 3 1/3 innings. He has the most losses of any pitcher in the major leagues this year.

The Orioles (80-59) opened a six-game homestand and hoped to get on a run after going only 5-5 in August home games.

It was the first game for the White Sox (31-108) since losing 2-0 to the New York Mets on Sunday to break the single-season franchise record for losses. Gavin Sheets and Corey Julks each provided two of the team’s eight hits.

Chicago started strong against Burnes (13-7). The first two batters reached base and Andrew Benintendi drove in the first run with a sacrifice fly in the first inning. Sheets drove in the next run with a single.

Henderson led off the bottom of the first with his 34th homer of the season. In the third inning, Anthony Santander drove in a run with a single and Slater had a run-scoring double to give the Orioles a 3-2 lead.

Baltimore tacked on two runs in the fifth and six more in the sixth for an 11-2 lead. Slater’s two-run single and Rivera’s two-run triple were highlights in the sixth.