The Buffalo Bills have ruled out wide receiver Curtis Samuel, linebacker Terrel Bernard and rookie defensive tackle DeWayne Carter for Sunday’s road game against the Seattle Seahawks.

Samuel (pectoral) and Bernard (ankle) did not practice Wednesday and Thursday, while Carter (wrist) was limited both days.

“We were trying to see how (Carter) was able to deal with things,” Bills coach Sean McDermott said Friday. “He’s going to end up having to get surgery, so he’s going to be out multiple weeks.”

McDermott said there’s “a good chance” that Carter ends up on injured reserve, but the Bills “don’t know if we’re there yet.”

The coach didn’t think Samuel would be placed on IR. “It may be more than one week,” McDermott said. “We’re just taking it one week at a time.”

The Bills are 5-2, and the Seahawks are 4-3.

Samuel, 28, has played as a reserve in seven games and has 12 receptions on 18 targets for 92 yards in his first season with Buffalo.

He has 329 career receptions for 3,475 yards and 22 touchdowns in 98 games (58 starts) for Carolina (2017-20), Washington (2021-23) and Buffalo. The Panthers selected Samuel in the second round of the 2017 NFL Draft out of Ohio State.

Bernard, 25, has played five games (all starts) this season and has 32 tackles, three tackles for loss and one interception. The Bills picked him in the third round of the 2022 draft out of Baylor. He has 197 tackles, 6.5 sacks, 13 tackles for loss, 10 quarterback hits, four interceptions and four fumble recoveries.

Carter, 23, was a third-round selection in the 2024 draft out of Duke. He has started two of seven games and has nine tackles, including three for loss, and two QB hits.